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Disruption of two-way active avoidance behavior produced by nimodipine
1Nencki Institute of Experimental Biology, Warsaw, Poland.
Pharmacology, Biochemistry, and Behavior
|March 1, 1994
Summary
Low doses of nimodipine impaired active avoidance learning and memory in rats. Nimodipine, a calcium channel blocker, demonstrated learning-disruptive effects, contrary to procognitive suggestions.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Nimodipine is a calcium channel blocker.
- Nimodipine has been proposed as a procognitive agent.
Purpose of the Study:
- To investigate the effects of low-dose nimodipine on learning and memory.
Main Methods:
- Rats received intraperitoneal injections of nimodipine (0.05 or 0.5 mg/kg).
- Two-way active avoidance behavior was assessed.
- Acquisition, performance, and extinction phases were analyzed.
Main Results:
- Low doses of nimodipine impaired active avoidance behavior acquisition.
- Nimodipine-treated rats showed significantly lower performance levels.
- Faster extinction of learned behavior was observed in nimodipine-treated rats.
Conclusions:
- Nimodipine at low doses exhibits learning-disruptive effects.
- The procognitive potential of nimodipine is questionable under these conditions.