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Faecal DL-lactate concentration in 100 gastrointestinal patients
H Hove1, I Nordgaard-Andersen, P B Mortensen
1Dept. of Medicine A. Rigshospitalet, University of Copenhagen, Denmark.
Scandinavian Journal of Gastroenterology
|March 1, 1994
Summary
Elevated fecal DL-lactate levels are common in patients with active inflammatory bowel disease and proctitis, and occasionally seen in severe malabsorption cases. Normal levels were frequent in quiescent disease or localized Crohn
Area of Science:
- Gastroenterology
- Clinical Chemistry
- Microbiology
Background:
- Fecal lactate, specifically DL-lactate, is a potential biomarker for gastrointestinal disorders.
- Understanding its association with intestinal inflammation and malabsorption is crucial for diagnosis.
Purpose of the Study:
- To evaluate the relationship between fecal DL-lactate concentrations and intestinal inflammation or malabsorption.
- To determine the diagnostic utility of fecal DL-lactate in various gastrointestinal conditions.
Main Methods:
- Analyzed fecal DL-lactate concentrations in 100 nonselected inpatients with gastrointestinal disorders.
- Compared lactate levels against healthy individuals' reference range (6.1 mmol/l).
- Correlated lactate levels with diagnoses including inflammatory bowel disease (IBD), proctitis, malabsorption, and Crohn's ileitis.
Main Results:
- 21% of patients exhibited elevated fecal DL-lactate (>6.1 mmol/l).
- Increased DL-lactate was observed in 73% of IBD patients with active proctitis and 18-33% of patients with malabsorption.
- Normal lactate levels were frequent in quiescent IBD (4%) and localized Crohn's ileitis.
Conclusions:
- Fecal DL-lactate is frequently elevated in inflammatory bowel disease with proctitis and occasionally in severe malabsorption.
- Fecal lactate measurement may serve as a useful indicator in specific gastrointestinal inflammatory conditions.
- Further research into lactate isomers (L-lactate and D-lactate) may provide additional diagnostic insights.