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[Insulin pumps and drop in pressure]

L Aanderud1, E M Hansen

  • 1Avdeling for anestesi og intensivmedisin, Haukeland Sykehus, Bergen.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|February 20, 1994
PubMed
Summary

Insulin pumps may deliver slightly more insulin at lower environmental pressures. This increased delivery is due to dissolved gases in insulin solutions, not pump malfunction.

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Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Environmental Science

Background:

  • Insulin pumps are crucial for diabetes management, delivering precise insulin doses.
  • Understanding device performance under varying environmental conditions, such as lower atmospheric pressure, is essential for patient safety.

Purpose of the Study:

  • To investigate whether insulin pumps deliver increased insulin volumes at reduced environmental pressures.
  • To determine if observed increases in insulin delivery are attributable to pump malfunction or physical changes in the insulin solution.

Main Methods:

  • Four insulin pump models (H-TRON V-100, MRS-1, Nordic Infusor MK II, Minimed 504-S) were tested at simulated environmental pressures of 0.9 ATA and 0.8 ATA.
  • Constant infusion rates of 2.0 I.U./hour were maintained.
  • The H-TRON V-100 was further evaluated at 0.7 ATA and with the motor disengaged.

Main Results:

  • All tested insulin pumps exhibited a slight increase in insulin delivery during decompression (lower pressures).
  • Maximum extra delivery observed was 2.68 I.U. at 0.7 ATA and an average of 1.32 I.U. at 0.8 ATA.
  • A comparable amount of extra insulin (1.72 I.U.) was delivered at 0.7 ATA even when the pump motor was stopped.

Conclusions:

  • The increased insulin delivery at lower environmental pressures is primarily caused by the release of physically dissolved gases (nitrogen and oxygen) from the insulin solution.
  • The observed phenomenon is a physical effect related to the insulin solution, not a sign of pump dysfunction.

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