Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid function in changing weather in a subtropical region

G K Rastogi, R C Sawhney

    Metabolism: Clinical and Experimental
    |August 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impotency in Male Diabetics.

    Indian journal of dermatology and venereology·2017
    Same author

    Personality pattern of parents of mentally retarded children.

    Indian journal of psychiatry·2011
    Same author

    Correlation study among water quality parameters an approach to water quality management.

    Journal of environmental science & engineering·2010
    Same author

    Safety and healing efficacy of Sea buckthorn (Hippophae rhamnoides L.) seed oil on burn wounds in rats.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2009
    Same author

    Cytoprotective and antioxidant activity of seabuckthorn (Hippophae rhamnoides L.) flavones against tert-butyl hydroperoxide-induced cytotoxicity in lymphocytes.

    Journal of medicinal food·2009
    Same author

    A poly-herbal formulation accelerates normal and impaired diabetic wound healing.

    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2009
    Same journal

    Ablation of microglial estrogen receptor alpha predisposes male mice to diet-induced obesity.

    Metabolism: clinical and experimental·2026
    Same journal

    Pathophysiology-based subtypes of individuals at high-risk of type 2 diabetes: multi-omics profiles and lifestyle differences across subtypes.

    Metabolism: clinical and experimental·2026
    Same journal

    A thermosensitive TET-Parkin epigenetic axis couples mitochondrial quality control to adaptive thermogenesis in adipose tissue.

    Metabolism: clinical and experimental·2026
    Same journal

    Raffinose targets the NQO1/NF-κB axis to attenuate DON-driven microglial activation and neuroinflammation via metabolic reprogramming.

    Metabolism: clinical and experimental·2026
    Same journal

    Endothelial NPR-C promotes insulin resistance via Caveolin-1-mediated insulin transcytosis.

    Metabolism: clinical and experimental·2026
    Same journal

    Macrophage-enriched GPR91 aggravates acute liver injury by inhibiting efferocytosis via the AC/cAMP/PPARγ pathway.

    Metabolism: clinical and experimental·2026
    See all related articles

    Thyroid hormone (T3 and T4) urinary excretion increases in colder months, suggesting enhanced thyroid hormone availability to aid adaptation to cold through increased thermogenesis.

    Area of Science:

    • Endocrinology
    • Environmental Physiology
    • Human Metabolism

    Background:

    • Thyroid hormones play a crucial role in regulating metabolism and body temperature.
    • Seasonal variations in environmental temperature can influence physiological processes.
    • Understanding thyroid hormone dynamics in response to temperature is important for human adaptation.

    Purpose of the Study:

    • To investigate the seasonal variations in thyroid hormone (T3 and T4) levels and excretion in healthy men.
    • To assess the relationship between environmental temperature and thyroid hormone metabolism.
    • To determine if thyroid hormone responses to TRH differ between seasons.

    Main Methods:

    • Collected monthly serum and 24-hr urine samples from eight healthy men over one year.

    Related Experiment Videos

  • Measured serum thyroxine (T4), triiodothyronine (T3), thyrotropin (TSH), and urinary T3 and T4 using radioimmunoassays.
  • Assessed serum thyroxine-binding globulin (TBG) and thyroid hormone responses to TRH in different seasons.

    • Main Results:

    • Serum T3, T4, TSH, and TBG concentrations showed no significant seasonal variations.
    • Mean urinary excretion of T3 and T4 was significantly higher during the coldest months (January-February) compared to the hottest months (May-July).
    • Thyroid-stimulating hormone (TSH) and urinary T3/T4 responses to TRH did not differ significantly between summer and winter.

    Conclusions:

    • Increased urinary excretion of T3 and T4 during colder months suggests greater availability of free thyroid hormones.
    • This enhanced thyroid hormone availability may facilitate adaptation to cold environments by increasing non-shivering thermogenesis.
    • Urinary hormone excretion serves as an indirect indicator of unbound, biologically active hormone levels.