[Blood plasma cyclic nucleotides and compensatory-restorative processes in duodenal peptic ulcer]

Contents of cAMP and cGMP in blood plasma as well as ratio cAMP/cGMP were studied by radioimmunoassay in 56 patients with duodenal ulcer of various severity. The examination was performed twice: before the treatment and 4 weeks after the treatment in a hospital. The analysis carried out with regard to the treatment efficacy in every variant of the clinical course of the disease showed that poor treatment results are associated with the dynamics of cyclic nucleotide (CN) plasma levels, especially with the increased ratio cAMP/cGMP, regardless of the disease severity which is characteristic of blood plasma CN taking part in compensatory-adaptive mechanisms in duodenal ulcer and evidences the necessity of differentiated approach to the treatment in accordance with developed adaptive reactions.