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[The activity of the antioxidant system and membrane lipid peroxidation in hypertension patients]
Insights
This study reveals that increased lipid peroxidation and reduced antioxidant defenses in hypertonic disease patients correlate with left ventricle hypertrophy. These findings highlight the role of oxidative stress in cardiovascular changes.
Area of Science:
- Cardiology
- Biochemistry
- Pathophysiology
Background:
- Hypertonic disease (HD) is associated with significant cardiovascular complications.
- Understanding the role of oxidative stress in HD pathophysiology is crucial for patient management.
Purpose of the Study:
- To investigate the status of antioxidant protection and membrane lipid peroxidation (LPO) in patients with hypertonic disease (HD).
- To correlate these biochemical markers with the structural and functional state of the myocardium.
Main Methods:
- Echocardiography was used to assess myocardial structure and function in 200 HD patients (Stages I-II).
- Erythrocyte enzymatic and non-enzymatic LPO, catalase, and superoxide-dismutase activity were analyzed.
Main Results:
- Patients with HD exhibited activated LPO and altered antioxidant potential.
- These changes in membrane destabilization and antioxidant capacity were directly correlated with the degree of left ventricle hypertrophy.
Conclusions:
- Lipid peroxidation activation and diminished antioxidant potential are key features in hypertonic disease.
- These oxidative stress markers are closely linked to the development of left ventricle hypertrophy in HD patients.
Abstract:
With the view to study state of antioxidant protection and membrane lipid peroxidation (LPO) in hypertonic disease (HD) 200 patients with HD of I and II stage (WHO classification) were examined. Structural and functional state of myocardium was assessed echocardiographically. Enzymatic and non-enzymatic LPO, catalase and superoxide-dismutase activity were analyzed in erythrocytes. Destabilization of cell membranes due to LPO activation and alteration of antioxidant potential established in patients with HD was paralleled by the degree of left ventricle hypertrophy.