Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

From EEG source localization to source imaging

M Scherg1

  • 1Department of Neuroscience, Albert Einstein College of Medicine, New York.

Acta Neurologica Scandinavica. Supplementum
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ictal and interictal electric source imaging in pre-surgical evaluation: a prospective study.

European journal of neurology·2018
Same author

A source analysis of the late human auditory evoked potentials.

Journal of cognitive neuroscience·2013
Same author

Influences of skull segmentation inaccuracies on EEG source analysis.

NeuroImage·2012
Same author

Combined spike-related functional MRI and multiple source analysis in the non-invasive spike localization of benign rolandic epilepsy.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2007
Same author

Is frontal lobe involved in the generation of auditory evoked P50?

Neuroreport·2001
Same author

Interaction of tactile input in the human primary and secondary somatosensory cortex--a magnetoencephalographic study.

NeuroImage·2001
Same journal

Sleep quality and arousal in migraine and tension-type headache: the headache-sleep study.

Acta neurologica Scandinavica. Supplementum·2014
Same journal

Diffusion-weighted lesions in acute ischaemic stroke patients with migraine.

Acta neurologica Scandinavica. Supplementum·2014
Same journal

Mild stroke: safety and outcome in patients receiving thrombolysis.

Acta neurologica Scandinavica. Supplementum·2014
Same journal

MRI evaluation of grey matter atrophy and disease course in multiple sclerosis: an overview of current knowledge.

Acta neurologica Scandinavica. Supplementum·2014
Same journal

Myasthenia gravis epidemiology in a national cohort; combining multiple disease registries.

Acta neurologica Scandinavica. Supplementum·2014
Same journal

Advances in genetic diagnosis of neurological disorders.

Acta neurologica Scandinavica. Supplementum·2014
See all related articles

A new functional imaging technique, FOCUS, creates brain images from scalp EEG. This method revealed distinct temporal lobe activities in epilepsy patients, unseen with traditional EEG.

Area of Science:

  • Neuroimaging
  • Epilepsy Research
  • Brain Activity Mapping

Background:

  • Scalp electroencephalography (EEG) traditionally offers limited spatial resolution for brain activity.
  • Understanding the precise localization and propagation of epileptic activity is crucial for effective treatment.

Purpose of the Study:

  • To introduce and validate a novel functional imaging technique, FOCUS (Functional Ultrasound Source analysis).
  • To assess the capability of FOCUS in imaging brain source activities, specifically in temporal lobe epilepsy.

Main Methods:

  • Development of the FOCUS technique utilizing multiple spatio-temporal dipole models.
  • Application of FOCUS to scalp EEG data from patients with temporal lobe epilepsy.
  • Comparison of FOCUS-generated source activity patterns with scalp EEG and subdural recordings.

Related Experiment Videos

Main Results:

  • FOCUS successfully transformed scalp EEG into images of source activities, depicting spatial patterns and waveforms.
  • Distinct activities were identified at the basal and lateral aspects of the temporal lobe in epilepsy patients.
  • Source waveforms from FOCUS demonstrated propagation patterns consistent with subdural recordings, which were not discernible in standard scalp EEG.

Conclusions:

  • The FOCUS technique provides enhanced spatial resolution for brain activity imaging from scalp EEG.
  • FOCUS offers valuable insights into the localization and propagation of epileptic activity within the temporal lobe.
  • This novel technique holds promise for improving the diagnosis and understanding of neurological disorders like epilepsy.