Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cytogenetic patterns in Warthin tumor]

C Russo1, M Brunelli, P Baroli

  • 1Regione Lombardia, USSL 71, Divisione ORL Presidio Ospedaliero, Cuggiono MI.

Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societa Italiana Di Otorinolaringologia E Chirurgia Cervico-Facciale
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging in gynecological disease (30): clinical and ultrasound characteristics of usual-type and variants of leiomyoma.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Lack of neighbor perception in soft wheat increases weed-induced yield losses.

Journal of plant physiology·2025
Same author

Antiseptic activity of different ophthalmic formulations: an in vitro study.

European review for medical and pharmacological sciences·2025
Same author

Atypical suicide by single incising cut to the throat without hesitation marks: Case report and review of the literature.

Legal medicine (Tokyo, Japan)·2024
Same author

Reproducibility of #Enzian classification by transvaginal ultrasound and its correlation with symptoms.

Facts, views & vision in ObGyn·2024
Same author

An integrated approach for the assessment of the electrochemical oxidation of diclofenac: By-product identification, microbiological and eco-genotoxicological evaluation.

The Science of the total environment·2023
Same journal

Association between tracheo-oesophageal fistula and anti-angiogenic therapy in locally advanced/metastatic tumours. A narrative review.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2026
Same journal

Clinical utility and advances of liquid biopsy in hypopharyngeal carcinoma: a systematic review and meta-analysis.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2026
Same journal

Italian validation of the ENS6Q: a disease-specific questionnaire for empty nose syndrome.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2026
Same journal

Side correlation between subjective visual vertical tilt and symptoms in migraine with vertigo.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2026
Same journal

Italian translation, cross-cultural adaptation and validation of the Mayo Clinic Vestibular Schwannoma Quality of Life (VSQOL) Index.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2026
Same journal

A novel approach to hearing amplification: audiometric outcomes from Nuance Audio over-the-counter hearing aid glasses.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2026
See all related articles

Warthin's tumors, a type of benign salivary neoplasm, consistently show a normal karyotype in cytogenetical studies. This suggests that normal cells may represent neoplastic elements, indicating early chromosomal instability in tumor development.

Area of Science:

  • Cytogenetics
  • Oncology
  • Human Pathology

Background:

  • Benign and malignant salivary neoplasms in humans are under systematic study.
  • Chromosomal abnormalities are virtually always associated with tumors, potentially influencing initiation and progression.
  • Specific chromosome rearrangements are linked to particular cancers.

Observation:

  • Cytogenetical observations were made in five Warthin's tumors (adenolymphomas).
  • A direct chromosomal analysis method was employed, yielding successful banded metaphases.
  • All Warthin's tumors exhibited a stemline (S) with a normal karyotype.

Findings:

  • Normal cells constituted the sole stemline in two cases and the primary stemline in three others.
  • The presence of normal cells in Warthin's tumors is interpreted as potentially representing neoplastic elements, not stromal cells.

Related Experiment Videos

  • This contrasts with some interpretations of normal karyotypes in other benign tumor types.

    • Implications:

    • Benign tumors may originate with a normal stemline that develops chromosomal instability as an initial sign of neoplastic transformation.
    • Chromosomal instability, such as chromosome loss, could be an early indicator of neoplastic transformation in benign tumors.
    • Further research into the role of chromosomal abnormalities in the initiation and progression of salivary neoplasms is warranted.