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Related Experiment Videos

Diagnosing intestinal ischemia using a noncontact superconducting quantum interference device

J Golzarian1, D J Staton, J P Wikswo

  • 1Department of Surgery, Veterans Administration Medical Center, Nashville, Tennessee.

American Journal of Surgery
|June 1, 1994
PubMed
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Superconducting quantum interference device (SQUID) magnetometers can noninvasively detect changes in intestinal basic electric rhythm (BER) during ischemia. This technology shows promise for diagnosing mesenteric ischemia, even in humans.

Area of Science:

  • Biophysics
  • Gastroenterology
  • Medical instrumentation

Background:

  • Intestinal ischemia alters the small intestine's basic electric rhythm (BER).
  • Noninvasive monitoring of BER changes could aid in early diagnosis.

Purpose of the Study:

  • To investigate the feasibility of using a superconducting quantum interference device (SQUID) magnetometer to detect noninvasively changes in intestinal biomagnetic activity associated with ischemia.
  • To compare SQUID measurements with traditional electrical recordings of BER during induced intestinal ischemia in an animal model.

Main Methods:

  • Ten animals underwent laparotomy with jejunum isolation in a recording chamber.
  • Intestinal ischemia was induced via mesenteric artery thrombin injection, with blood flow monitored by laser doppler.

Related Experiment Videos

  • Biomagnetic activity was recorded using a SQUID magnetometer, alongside traditional electrode recordings in some animals.

    • Main Results:

    • Thrombin injection caused a 95% decrease in blood flow within 5 minutes.
    • SQUID measurements revealed significant decreases in BER frequency (15.5 to 8.9 cycles/min) and slow wave propagation velocity (3.5 to 1.9 sec/cycle) (P < 0.01).
    • Changes in biomagnetic activity mirrored those in electrical activity.

    Conclusions:

    • SQUID magnetometers can reliably detect intestinal ischemia in animal models through noncontact measurement of biomagnetic activity.
    • The findings support the potential for SQUID technology in the noninvasive diagnosis of mesenteric ischemia.
    • Human small bowel biomagnetic activity has been recorded, suggesting future clinical applications.