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The effect of nicotine and carbon monoxide on exercise performance in normal subjects
1Royal Bournemouth Hospital, U.K.
Abstract:
In a partially blind randomized control study, nine healthy adult men performed progressive sub-maximal exercise tests, either after chewing nicotine chewing gum (4 mg) or breathing carbon monoxide (320 p.p.m.). Neither agent significantly affected exercise performance, despite a mean rise in blood nicotine to 17.0 ng ml-1 during nicotine administration and a COHb rise to 6.9% whilst breathing carbon monoxide. There was a significant rise in heart rate and blood pressure (P < 0.01) after nicotine administration. The reasons for absence of significant effect on cardiovascular or respiratory performance are discussed.
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