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Early steps in fusion between Epstein-Barr virus and a human hepatoma cell line (Li7A)
1Instituto di Medicina Sperimentale, CNR, Roma, Italy.
Research in Virology
|July 1, 1993
Abstract:
Epstein-Barr virus, the causative agent of mononucleosis and several human cancers, infects cells via complement receptor type 2 (CR2). Expression of this receptor is restricted to B lymphocytes, some epithelial cells and immature thymocytes; expression of CR2-like proteins has been also found on T cells. In the present report, we identified the presence, on the membrane of Li7A cells, of a novel EBV receptor distinct from CR2 capable of triggering fusion with EBV virions with more rapid kinetics than that found with lymphoblastoid cells (Raji).