Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic lidocaine therapy for poststroke pain

E A Edmondson1, R K Simpson, D K Stubler

  • 1Department of Neurology, Baylor College of Medicine, Houston, Tex. 77030.

Southern Medical Journal
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A phase I and pharmacokinetic study of oxaliplatin and bortezomib: activity, but dose-limiting neurotoxicity.

Cancer chemotherapy and pharmacology·2013
Same author

Alternating verbal fluency performance following bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease.

European journal of neurology·2012
Same author

Treatment of chronic pain in failed back surgery patients with spinal cord stimulation: a review of current literature and proposal for future investigation.

Neuromodulation : journal of the International Neuromodulation Society·2011
Same author

Alleviation of drenching sweats following subthalamic deep brain stimulation in a patient with Parkinson's disease--a case report.

Journal of the neurological sciences·2009
Same author

Deep brain stimulation improves orthostatic regulation of patients with Parkinson disease.

Neurology·2006
Same author

Neuropsychological functioning following bilateral subthalamic nucleus stimulation in Parkinson's disease.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2004

Intravenous lidocaine infusion effectively relieved central poststroke pain in four patients. Mexiletine, an oral lidocaine derivative, provided sustained relief for two patients, suggesting a viable treatment option for neuropathic pain.

Area of Science:

  • Neurology
  • Pain Medicine
  • Pharmacology

Background:

  • Poststroke pain syndrome is a challenging condition often resistant to conventional treatments.
  • Central poststroke pain (CPSP) significantly impacts patient quality of life.

Observation:

  • Four patients with central poststroke pain received a 48-hour intravenous lidocaine infusion.
  • Pain intensity was assessed using visual analog and numeric rating scales.
  • All patients experienced pain relief within 12 hours of initiating the lidocaine infusion.

Findings:

  • Intravenous lidocaine demonstrated efficacy in reducing central poststroke pain.
  • Two patients continued mexiletine, an oral lidocaine congener, achieving excellent pain relief at 12 months.
  • Two patients discontinued mexiletine due to side effects.

Related Experiment Videos

Implications:

  • Lidocaine infusion represents a potential therapeutic strategy for intractable poststroke pain.
  • Mexiletine may offer a long-term oral treatment option for select patients.
  • The findings support the development of a treatment algorithm for neuropathic pain management.