Related Experiment Video

Updated: Jul 10, 2026

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
06:58

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat

Published on: July 26, 2015

Comparison between total and renal plasma clearance of [51Cr] EDTA

J B Mortensen, P Rödbro

    Scandinavian Journal of Clinical and Laboratory Investigation
    |May 1, 1976
    PubMed

    More Related Videos

    Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue11:22

    Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

    Published on: August 17, 2016

    A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods09:49

    A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

    Published on: April 24, 2020

    Related Concept Videos

    Renal Clearance01:23

    Renal Clearance

    The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
    Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
    Renal Drug Clearance: Overview01:06

    Renal Drug Clearance: Overview

    Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
    Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
    Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

    Renal Drug Clearance: Comparison Between Renal Excretion Methods

    Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
    Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
    Factors Affecting Renal Clearance: Renal Impairment01:17

    Factors Affecting Renal Clearance: Renal Impairment

    Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
    One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
    Determination of Renal Drug Clearance: Graphical and Midpoint Methods01:07

    Determination of Renal Drug Clearance: Graphical and Midpoint Methods

    Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
    The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
    Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

    Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

    In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...