[Synthetic antimycotica (author's transl)]

Area of Science:

• Veterinary Dermatology
• Mycology
• Pharmacology

Background:

• Dermatomycosis treatment involves antimycotic antibiotics and synthetic compounds.
• Synthetic antifungal agents vary widely in chemical structure and historical usage.
• Previous work detailed antimycotic antibiotics; this paper focuses on synthetic drugs.

Purpose of the Study:

• To review synthetic drugs used in treating dermatomycosis.
• To provide a comprehensive overview of their physicochemical and pharmacotoxicological properties.
• To discuss their antifungal spectrum, mechanisms of action, and available preparations.

Main Methods:

• Literature review of synthetic compounds for dermatomycosis treatment.
• Compilation of data on physicochemical properties.
• Analysis of pharmacotoxicological profiles, antifungal activity, and mechanisms.

Main Results:

• Identification of numerous synthetic compounds, some dating back to pre-1945.
• Categorization of agents based on chemical structure and therapeutic application.
• Summary of known properties, efficacy, and usage of these synthetic drugs.

Conclusions:

• Synthetic compounds represent a significant class of drugs for dermatomycosis management.
• Understanding their diverse properties is crucial for effective therapeutic selection.
• This review consolidates essential information on synthetic antifungals for veterinary use.