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[Synthetic antimycotica (author's transl)]

A S van Miert, J H van Soeren, F M Hagens

    Tijdschrift Voor Diergeneeskunde
    |August 15, 1976
    PubMed
    Summary

    This review covers synthetic drugs for treating dermatomycosis, including older and newer compounds. It details their properties, antifungal spectrum, mechanisms, and formulations.

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    Area of Science:

    • Veterinary Dermatology
    • Mycology
    • Pharmacology

    Background:

    • Dermatomycosis treatment involves antimycotic antibiotics and synthetic compounds.
    • Synthetic antifungal agents vary widely in chemical structure and historical usage.
    • Previous work detailed antimycotic antibiotics; this paper focuses on synthetic drugs.

    Purpose of the Study:

    • To review synthetic drugs used in treating dermatomycosis.
    • To provide a comprehensive overview of their physicochemical and pharmacotoxicological properties.
    • To discuss their antifungal spectrum, mechanisms of action, and available preparations.

    Main Methods:

    • Literature review of synthetic compounds for dermatomycosis treatment.
    • Compilation of data on physicochemical properties.
    • Analysis of pharmacotoxicological profiles, antifungal activity, and mechanisms.

    Main Results:

    • Identification of numerous synthetic compounds, some dating back to pre-1945.
    • Categorization of agents based on chemical structure and therapeutic application.
    • Summary of known properties, efficacy, and usage of these synthetic drugs.

    Conclusions:

    • Synthetic compounds represent a significant class of drugs for dermatomycosis management.
    • Understanding their diverse properties is crucial for effective therapeutic selection.
    • This review consolidates essential information on synthetic antifungals for veterinary use.

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