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Related Experiment Videos

Decrease of histamine induced bronchoconstriction by caffeine in mild asthma

J C Henderson1, F O'Connell, R W Fuller

  • 1Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.

Thorax
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

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Caffeine intake, even at low doses, can alter bronchial responsiveness in asthma patients. It is recommended to avoid caffeine for over four hours before bronchial provocation testing.

Area of Science:

  • Pulmonary Medicine
  • Pharmacology

Background:

  • Limited data exists on the impact of low-dose caffeine (< or = 5 mg/kg) on pulmonary function and bronchial challenge tests in mild asthma.
  • Unlike theophylline, caffeine is not currently recommended for withholding before bronchoprovocation and pulmonary function testing.

Purpose of the Study:

  • To evaluate the effect of a single oral dose of caffeine (5 mg/kg) on FEV1 and histamine bronchial responsiveness in patients with mild stable asthma.

Main Methods:

  • A double-blind, placebo-controlled study was conducted.
  • Eight patients with mild stable asthma participated.
  • Assessed FEV1 and bronchial responsiveness to histamine after caffeine administration.

Main Results:

  • Caffeine did not significantly affect FEV1.

Related Experiment Videos

  • Mean log PC20 histamine was significantly higher at 150 and 240 minutes post-caffeine compared to placebo.
  • This indicates reduced bronchial responsiveness after caffeine intake.

    • Conclusions:

    • Caffeine intake should be avoided for more than four hours prior to bronchial provocation testing.
    • Further research is needed to determine the precise duration for caffeine exclusion.