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[Hearing loss after erythromycin therapy]

O Lind1, S Harthug

  • 1Ore-nese-halsavdelingen, Haukeland Sykehus, Bergen.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|September 20, 1993
PubMed
Summary
This summary is machine-generated.

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High-dose erythromycin treatment can cause hearing loss. Patients with impaired kidney or liver function, or on diuretics and aminoglycosides, may be at higher risk for this ototoxicity.

Area of Science:

  • Otolaryngology
  • Pharmacology
  • Nephrology

Background:

  • Erythromycin is a commonly prescribed macrolide antibiotic.
  • Ototoxicity is a known potential side effect of various medications.
  • Factors influencing drug toxicity include renal and hepatic function.

Observation:

  • A patient undergoing intravenous erythromycin therapy developed bilateral hearing loss.
  • The patient had pre-existing reduced renal and hepatic function.
  • Concomitant treatment included diuretics and aminoglycosides.

Findings:

  • Intravenous erythromycin administration was associated with reversible hearing impairment.
  • The patient experienced late but substantial recovery of hearing.
  • Potential contributing factors included compromised organ function and concurrent nephrotoxic/ototoxic drug use.

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Implications:

  • Routine audiological monitoring and questioning about hearing loss and tinnitus are recommended for patients on high-dose erythromycin.
  • Awareness of potential ototoxicity is crucial, especially in vulnerable patient populations.
  • This case highlights the importance of considering cumulative drug effects and patient-specific risk factors.