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Formation of 18-deoxy-19-noraldosterone by a human aldosterone-producing adenoma
1Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Steroids
|June 1, 1993
Abstract:
The recently synthesized 18-deoxy-19-noraldosterone is a potent aldosterone antagonist. In the present study we demonstrate the in vitro formation of 18-deoxy-19-noraldosterone from 19-noraldosterone in a human aldosterone-producing adenoma and normal adrenal tissue. The metabolite was isopolar, cochromatographed with the authentic standard on high-performance liquid chromatography, and the identity was further analyzed by mass spectrometry. The possible role of 18-deoxy-19-noraldosterone in primary aldosteronism is also discussed.