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[Psoriasis and cancer]

J H Olsen1, G Frentz, H Møller

  • 1Sektor for Kraeftepidemiologi, Kraeftens Bekaempelse, København.

Ugeskrift for Laeger
|August 30, 1993
PubMed
Summary
This summary is machine-generated.

Individuals with psoriasis face a significantly higher risk of developing nonmelanoma skin cancer and several non-cutaneous cancers, including lung, larynx, pharynx, colon, and kidney cancers.

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Area of Science:

  • Dermatology and Oncology
  • Epidemiology

Context:

  • Psoriasis is a chronic inflammatory skin condition affecting a significant portion of the population.
  • Previous research suggests a potential link between psoriasis and an increased risk of certain cancers.
  • Understanding cancer incidence in psoriasis patients is crucial for risk assessment and management.

Purpose:

  • To investigate the cancer incidence among a large cohort of patients diagnosed with psoriasis.
  • To identify specific cancer types with elevated risk in individuals with psoriasis.

Summary:

  • A study of 6910 Danish patients diagnosed with psoriasis between 1977-1987 revealed a 2.5-fold increased risk of nonmelanoma skin cancer.
  • Significant increases in non-cutaneous cancers were observed, including lung cancer (RR 1.4-1.6), larynx/pharynx cancer in men (RR 2.8-3.9), and colon/kidney cancer in women (RR 1.6-2.3).

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  • While smoking's effect was unassessable, antipsoriatic treatments like radiation and arsenicals are potential contributing factors, especially for colon, kidney, and lung cancers.

    • Impact:

    • This study highlights the importance of cancer surveillance in patients with psoriasis.
    • Findings suggest potential links between psoriasis treatments and specific cancer risks, warranting further investigation.
    • Results contribute to a better understanding of the complex relationship between psoriasis and cancer etiology.