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Related Experiment Videos

Rare-earth elements in urinary calculi

K Höbarth1, C Koeberl, J Hofbauer

  • 1Department of Urology, University of Vienna, Austria.

Urological Research
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Rare-earth elements (REEs) accumulate in kidney stones. Phosphate stones show significantly higher concentrations of heavy REEs compared to oxalate stones, suggesting a potential role in stone formation.

Area of Science:

  • Geochemistry
  • Biomineralization
  • Nephrology

Background:

  • Trace elements influence urinary stone crystallization.
  • The role of rare-earth elements (REEs) in human physiology and their impact on calcium transport are poorly understood.
  • Urinary stones can concentrate REEs.

Purpose of the Study:

  • To analyze the rare-earth element (REE) patterns in human kidney stones.
  • To investigate potential differences in REE concentrations between oxalate and phosphate stones.

Main Methods:

  • Neutron-activation analysis was used to determine REE concentrations.
  • Ten human kidney stones (six oxalate, four phosphate) were analyzed.

Main Results:

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  • Urinary stones concentrate REEs, with some fractionation of light and heavy REEs observed.
  • Significantly elevated concentrations of heavy REEs (Europium, Terbium, Lutetium) were found in phosphate stones compared to oxalate stones (P < 0.005).

    • Conclusions:

    • Phosphate kidney stones exhibit distinct REE profiles, with higher heavy REE content.
    • These findings suggest a potential association between heavy REE accumulation and the formation of phosphate urinary stones.