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Related Experiment Videos

Atherosclerosis--reversal with therapy

D H Blankenhorn1, H N Hodis

  • 1Atherosclerosis Research Institute, University of Southern California School of Medicine, Los Angeles 90033.

The Western Journal of Medicine
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

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Atherosclerosis reversal is possible, shown in animal and human studies. Further research is needed to identify optimal interventions targeting cellular processes for effective atherosclerosis regression.

Area of Science:

  • Cardiovascular Science
  • Pathology
  • Biochemistry

Background:

  • Atherosclerosis reversal evidence stems from animal models, human autopsy studies, and angiographic trials.
  • Detailed histologic and biochemical descriptions of regression exist, but direct observation of lesion changes in the same subjects is lacking.
  • Current understanding of atherogenesis involves endothelial permeability, platelet adherence, immune cell infiltration, and smooth muscle cell proliferation.

Purpose of the Study:

  • To review the evidence for atherosclerosis reversal.
  • To elucidate the cellular and molecular mechanisms underlying atherogenesis and potential regression.
  • To identify optimal targets for future therapeutic interventions.

Main Methods:

  • Review of animal studies involving induced atherosclerosis and regression.

Related Experiment Videos

  • Analysis of autopsy data from starved human populations.
  • Examination of angiographic studies evaluating anti-atherosclerosis treatments.
  • Synthesis of data from studies on isolated arterial cell systems and intact arterial lesions.

    • Main Results:

    • Animal models and autopsy studies provide detailed descriptions of regression.
    • Atherogenesis involves increased endothelial permeability, lipoprotein uptake, inflammatory cell recruitment, and smooth muscle cell proliferation.
    • Reducing known risk factors can lessen atherosclerosis, but direct cellular event information is limited from angiographic trials.
    • Evidence suggests regression is possible, but consensus on optimal therapy is lacking.

    Conclusions:

    • Atherosclerosis reversal is supported by multiple lines of evidence.
    • Key processes in atherogenesis offer potential targets for intervention.
    • Future trials should focus on optimizing therapies based on a deeper understanding of cellular mechanisms for effective atherosclerosis regression.