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Transient increase of aminotransferases in RA patients treated with methotrexate
J K Lacki1, W Samborski, S H Machiewicz
1Department of Immunology and Rheumatology, Karol Marcinkowski University, School of Medicine, Poznan, Poland.
Zeitschrift Fur Rheumatologie
|July 1, 1993
Abstract:
Sixty-two patients with rheumatoid arthritis (RA) were treated with methotrexate (MTX) for 3 months. Methotrexate was given orally in a single dose of 7.5-15.0 mg/week. At the onset of the treatment increased activity of aminotransferases has been observed. Eighteen patients (29%) displayed higher enzyme activity in the first 3 weeks. Despite the continuous drug administration the activity of aminotransferase became normal at week 12 in all but one patient. In this patient MTX had to be withdrawn.