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Related Experiment Videos

Lipoprotein(a) and postmenopausal oestrogen

E Farish1, H A Rolton, J F Barnes

  • 1Department of Biochemistry, Stobhill Hospital, Glasgow, UK.

Acta Endocrinologica
|September 1, 1993
PubMed
Summary

Postmenopausal estrogen therapy may not significantly alter lipoprotein(a) levels. This study found no consistent pattern of change in lipoprotein(a) after 4 months of oestradiol valerate treatment in women.

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Lipid Metabolism

Background:

  • Epidemiological studies link postmenopausal estrogen therapy to reduced cardiovascular and cerebrovascular disease risk.
  • Estrogen's cardioprotective effects are partly mediated by changes in lipoproteins, especially high-density lipoprotein.
  • The role of lipoprotein(a) in estrogen's protective effects remains to be fully elucidated.

Purpose of the Study:

  • To investigate the effect of postmenopausal estrogen therapy on lipoprotein(a) levels.
  • To determine if changes in lipoprotein(a) can explain the reduced risk of coronary heart disease and stroke associated with estrogen therapy.

Main Methods:

  • A study involving 18 women who underwent hysterectomy and bilateral oophorectomy.
  • Serum samples were collected to measure lipoprotein(a) levels before and after 4 months of treatment with 2 mg/day oestradiol valerate.

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  • Participants had no prior hormonal therapy.

    • Main Results:

    • Lipoprotein(a) levels varied widely, from 35 to 720 mg/l (median 180 mg/l) pre-treatment.
    • Post-treatment, levels ranged from 55 to 780 mg/l (median 130 mg/l).
    • No consistent pattern of change in lipoprotein(a) was observed after oestradiol treatment.

    Conclusions:

    • Low-dose, unopposed estrogen therapy appears to have a limited short-term effect on lipoprotein(a) levels.
    • Further research is needed to understand the complex relationship between estrogen therapy, lipoprotein(a), and cardiovascular outcomes.