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Primary central white matter degeneration in old dogs
I Ferrer1, M Pumarola, R Rivera
1Unit of Neuropathology, Hospital Principes de Espana, University of Barcelona, Spain.
Acta Neuropathologica
|January 1, 1993
Abstract:
Degeneration of the central white matter is described in old dogs. The presence of ubiquitin-immunoreactive free granules and intracytoplasmic globules in glial cells and macrophages, together with galacerebroside-immunoreactive precipitates and lipofusion storage, point to the likelihood of a primary myelin degeneration with deposits of non-degraded ubiquitin-protein conjugates and complex galactolipids.