Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

NSAID effect on sporadic colon polyps

L J Hixson1, D L Earnest, M B Fennerty

  • 1Department of Medicine, University of Arizona Health Sciences Center, Tucson.

The American Journal of Gastroenterology
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal reflux disease and related neoplasia.

Alimentary pharmacology & therapeutics·2011
Same author

Randomised clinical trial: MiraLAX vs. Golytely - a controlled study of efficacy and patient tolerability in bowel preparation for colonoscopy.

Alimentary pharmacology & therapeutics·2010
Same author

Heartburn: an overview.

Postgraduate medicine·2009
Same author

Heartburn in the community.

Postgraduate medicine·2009
Same author

Clinical trial: lansoprazole 15 or 30 mg once daily vs. placebo for treatment of frequent nighttime heartburn in self-treating subjects.

Alimentary pharmacology & therapeutics·2009
Same author

Increased colonic transit in rats produced by a combination of a cholinesterase inhibitor with a 5-HT4 receptor agonist.

Neurogastroenterology and motility·2009
Same journal

Calendar of Courses, Symposiums and Conferences.

The American journal of gastroenterology·2026
Same journal

Molecular Nonendoscopic Tests for the Early Detection of Esophageal Squamous Carcinoma and High-Grade Dysplasia: Promising Progress.

The American journal of gastroenterology·2026
Same journal

ACG Clinical Guideline: Colonic Diverticulitis.

The American journal of gastroenterology·2026
Same journal

Continuing Medical Education Questions: July 2026.

The American journal of gastroenterology·2026
Same journal

Continuing Medical Education Questions: July 2026.

The American journal of gastroenterology·2026
Same journal

2026 CME Information.

The American journal of gastroenterology·2026
See all related articles

This pilot study investigated if sulindac or piroxicam promote regression of colon adenomatous polyps. Neither drug showed significant polyp regression after six months of therapy.

Area of Science:

  • Gastroenterology
  • Medical Oncology
  • Pharmacology

Background:

  • Colorectal cancer is a significant health concern.
  • Adenomatous polyps are precursors to colorectal cancer.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown potential in polyp prevention.

Purpose of the Study:

  • To evaluate the efficacy of sulindac and piroxicam in promoting the regression of existing adenomatous colonic polyps.
  • To assess the safety and tolerability of long-term NSAID therapy for polyp regression.

Main Methods:

  • An open-label pilot study involving patients with left-sided colonic polyps (3-12 mm).
  • Patients received either sulindac (400 mg/daily) or piroxicam (20 mg/daily) for six months.
  • Polyp size was measured at baseline, 3 months, and 6 months. Examiners were not blinded.

Related Experiment Videos

Main Results:

  • Seven patients completed the six-month therapy (five on sulindac, two on piroxicam).
  • One sulindac patient experienced complete polyp disappearance; others showed partial regression or no change.
  • One piroxicam patient had partial polyp regression; another experienced adverse events leading to withdrawal.

Conclusions:

  • Six months of sulindac or piroxicam therapy did not demonstrate significant regression of sporadic colon adenomatous polyps in this small pilot study.
  • Further research with larger sample sizes and controlled designs is warranted to explore NSAID effects on established polyps.