Related Experiment Videos
Possible association between the hernia of Morgagni and trisomy 21
L H Honoré1, C P Torfs, C J Curry
1Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
American Journal of Medical Genetics
|August 15, 1993
Abstract:
Of the 5 liveborn infants with the hernia of Morgagni recorded in the California Birth Defects Monitoring Program, 3 had trisomy 21. This significant association (P < 10(-6)) between the hernia of Morgagni and trisomy 21 may reflect defective dorsoventral migration of rhabdomyoblasts from the paraxial myotomes, caused by increased cellular adhesiveness in trisomy 21.