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Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
Selected problems treated by vocal fold injection of collagen
American Journal of Otolaryngology
|July 1, 1993
Summary
Bovine collagen injections improved vocal fold function in patients unsuitable for other treatments. This safe procedure showed significant gains in voice quality and intensity for glottic insufficiency.
Area of Science:
- Otolaryngology
- Speech Pathology
- Biomaterials
Background:
- Vocal fold injection is a therapeutic option for glottic insufficiency.
- Bovine collagen is a potential injectable material for vocal fold augmentation.
Purpose of the Study:
- To evaluate the efficacy and safety of bovine collagen injections in patients with glottic insufficiency.
- To assess outcomes in patients who are not candidates for alternative treatments.
Main Methods:
- A cohort of 45 patients with scarred vocal folds, bilateral vocal fold pathology, or unilateral vocal fold atrophy received bovine collagen injections.
- Outcomes were assessed using patient self-evaluation, perceptual voice analysis, acoustic signal analysis, aerodynamic measures, and videostroboscopy.
Main Results:
- The majority of patients experienced improvement, with statistically significant enhancements in jitter (P=.002), shimmer (P=.002), and maximum intensity (P=.026).
- No major complications or hypersensitivity reactions were reported.
- Marginal improvements were documented across various assessment measures.
Conclusions:
- Bovine collagen injection is a potentially useful and safe treatment for selected patients with glottic insufficiency.
- The procedure offers improved vocal function in difficult-to-treat patient populations.
- Further clinical research is recommended to confirm these findings.
