Familial schizencephaly
A C Hilburger1, J K Willis, E Bouldin
1Department of Psychiatry and Neurology, Tulane University Medical Center, New Orleans, LA 70112.
Abstract:
Schizencephaly is a brain malformation characterized by infolding of cortical gray matter along a hemispheric cleft near the primary cerebral fissures. Although the etiology is unknown, genetic counseling has not been advocated because of its sporadic occurrence. We describe a family with two affected siblings. Both cases were characterized by hemiparesis, lack of gestational or postnatal complications, and diagnostic radiologic findings. We raise the possibility of a genetic etiology in some cases of schizencephaly and suggest a re-examination of the need for genetic counseling.
Related Concept Videos
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Psychological and Sociocultural Causes of Schizophrenia
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Prosopagnosia
Sex-linked Disorders

