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Related Experiment Videos

Aspirin prophylaxis in migraine

B P O'Neill, J D Mann

    Lancet (London, England)
    |December 2, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Aspirin prophylaxis significantly reduced migraine headache frequency by over 50% in most patients. This pilot study suggests aspirin is an effective option for migraine prevention.

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    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Migraine is a common neurological disorder.
    • Effective prophylactic treatments are needed.

    Purpose of the Study:

    • To evaluate the efficacy of aspirin for migraine prophylaxis.

    Main Methods:

    • Prospective, double-blind, placebo-controlled trial.
    • 12 patients with migraine were included.

    Main Results:

    • Aspirin reduced headache frequency by >50% in 9/12 patients.
    • Response did not correlate with patient demographics or platelet ultrastructure.
    • Aspirin response may be linked to increased platelet aggregation.

    Conclusions:

    • Aspirin appears effective for migraine prophylaxis.
    • Further research into the mechanism is warranted.