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Hemostasis in cows with endotoxin-induced mastitis
E G Welles1, M A Williams, J W Tyler
1Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849.
American Journal of Veterinary Research
|August 1, 1993
Summary
Endotoxemia in cows alters blood clotting (hemostasis). Escherichia coli endotoxin caused significant changes in clotting tests, indicating an inflammatory response affecting blood coagulation.
Area of Science:
- Veterinary Medicine
- Hematology
- Toxicology
Background:
- Endotoxemia and mastitis are significant health concerns in dairy cows.
- Escherichia coli endotoxin is a primary cause of these conditions.
- Understanding the impact on hemostasis is crucial for effective treatment.
Purpose of the Study:
- To evaluate the effects of experimentally induced endotoxemia and mastitis on hemostasis in cows.
- To identify specific alterations in blood clotting parameters following endotoxin administration.
Main Methods:
- Cows were infused with Escherichia coli endotoxin to induce endotoxemia and mastitis.
- Hemostatic tests were performed, including prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, fibrin(ogen) degradation products, platelet count, antithrombin-III, and plasminogen activity.
- Blood samples were collected at 3, 12, and 24 hours post-infusion and compared to pre-infusion baseline values.
Main Results:
- Significant changes were observed in multiple hemostatic analytes.
- Increased prothrombin time and thrombin time (initially).
- Decreased activated partial thromboplastin time, fibrinogen, plasminogen activity, and platelet concentration were noted.
Conclusions:
- Experimentally induced endotoxemia in cows activates hemostatic mechanisms.
- These alterations are likely initiated by direct endotoxin effects or inflammatory mediators.
- Findings highlight the complex interplay between infection, inflammation, and blood coagulation in bovine health.