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Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro
T Wisniewski1, E Castano, J Ghiso
1Department of Pathology, New York University Medical Center, NY 10016.
Annals of Neurology
|October 1, 1993
Abstract:
Alzheimer's disease is characterized by the deposition of beta-protein (A beta) as amyloid. Recently, it was found that A beta is a normal component of serum and cerebrospinal fluid. Synthetic peptides homologous to A beta form amyloid-like fibrils spontaneously in water or physiological solutions. Using a peptide homologous to A beta 1-40, we find that fibril formation is inhibited by the presence of cerebrospinal fluid.