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Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia
R R Tidwell1, S K Jones, N A Naiman
1Department of Pathology, School of Medicine, University of North Carolina, Chapel Hill 27599.
Antimicrobial Agents and Chemotherapy
|August 1, 1993
Abstract:
On the basis of a previously observed correlation between the antimicrobial activity and DNA binding strength of dicationic molecules, a series of 10 dicationically substituted bis-benzimidazoles were tested for activity in the rat model of Pneumocystis carinii pneumonia. One of the compounds, 1,4-bis[5-(2-imidazolinyl)-2-benzimidazolyl]butane, was found to be more potent and less toxic than pentamidine.