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Effects of paraquat on Escherichia coli: sensitivity to small changes in pH of the medium--a cautionary note
1Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710.
Archives of Biochemistry and Biophysics
|November 1, 1993
Abstract:
Uric acid appears to protect Escherichia coli against the growth-inhibiting effect of paraquat, but this is actually due to acidification of the medium and does not occur when the pH of the medium is readjusted to neutrality. Any compound which lowers the pH of the medium will thus diminish the effect of paraquat on E. coli, whether that effect is inhibition of growth or adaptive induction of members of the soxRS regulon.