Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Chemotherapy for soft tissue sarcoma--current concepts and review]

T Umeda1, T Ishii, K Hatakeyama

  • 1Dept. of Orthopedic Surgery, National Cancer Hospital East.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|October 1, 1993
PubMed
Summary

Chemotherapy for soft tissue sarcoma, excluding rhabdomyosarcoma, shows limited survival benefits. Doxorubicin and ifosfamide offer response rates but lack established adjuvant value, necessitating further research for improved prognoses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlation between imatinib pharmacokinetics and clinical response in Japanese patients with chronic-phase chronic myeloid leukemia.

Clinical pharmacology and therapeutics·2010
Same author

Cytopathological alterations and therapeutic approaches in Binswanger's disease.

Neuropathology : official journal of the Japanese Society of Neuropathology·2009
Same author

Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentation in the rat.

Acta neuropathologica·2003
Same author

X-ray absorption spectral analyses by theoretical calculations for TiO2 and Ni-doped TiO2 thin films on glass plates.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry·2002
Same author

Caudoputamen is damaged by hypocapnia during mechanical ventilation in a rat model of chronic cerebral hypoperfusion.

Stroke·2001
Same author

Cytomorphologic diagnosis of malignant lymphoma arising in the heart: a case report.

Acta cytologica·2001

Area of Science:

  • Medical Oncology
  • Cancer Research
  • Pharmacology

Context:

  • The efficacy of chemotherapy in soft tissue sarcoma (STS) management, excluding rhabdomyosarcoma, is debated.
  • Advanced STS treatment often involves cytotoxic agents with varying response rates.

Purpose:

  • To review the current evidence on chemotherapy's role in advanced soft tissue sarcoma.
  • To evaluate the effectiveness and limitations of specific chemotherapeutic agents and combinations in STS treatment.

Summary:

  • Randomized trials indicate doxorubicin and ifosfamide as single agents yield response rates over 20% in advanced STS.
  • Doxorubicin-based combinations like ADIC and CYVADIC demonstrate higher response rates.
  • Ifosfamide combined with doxorubicin shows significant activity but is associated with increased toxicity.

Related Experiment Videos

  • The benefit of adjuvant chemotherapy in STS remains unproven, with most studies showing no survival advantage.

    • Impact:

    • Current chemotherapy regimens offer modest response rates but limited survival benefits in advanced STS.
    • Further research is crucial to establish the value of adjuvant chemotherapy and improve outcomes for high-grade malignant STS.
    • Understanding the complex role of chemotherapy is essential for developing more effective treatment strategies and improving patient prognosis.