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Treatment of Paget's disease of bone with single dose intravenous pamidronate
R A Watts1, S J Skingle, M M Bhambhani
1Department of Rheumatology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Objectives:
To assess the efficacy of a single intravenous infusion of pamidronate in Paget's disease of bone.
Methods:
Fourteen patients with active Paget's disease (raised serum alkaline phosphatase, bone pain or neurological involvement) were treated with a single intravenous infusion of 105 mg pamidronate. Patients were assessed for biochemical and clinical improvement for up to two years following treatment. A further infusion was given following symptomatic relapse (pain at a known site of pagetic involvement).
Results:
Serum alkaline phosphatase fell following treatment, with a nadir 5.9 months after treatment. Bone pain was improved in nine of 12 patients after six months. Retreatment of four patients resulted in a similar response.
Conclusion:
Single dose intravenous pamidronate (105 mg) is a convenient and effective treatment for Paget's disease.