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Synthesis and antitumor activity of some new 2-chloroethylnitrosoureas
E Filippatos1, A Papadaki-Valiraki, C Roussakis
1Department of Pharmaceutical Chemistry, University of Athens, Greece.
Archiv Der Pharmazie
|August 1, 1993
Abstract:
The synthesis of a series of N-(2-chloroethyl)-N'-(9H-xanthen-9-yl)-N-nitrosoureas and N-(2-chloroethyl)-N'-(9H-thioxanthen-9-yl)-N-nitrosoureas is described. The title compounds were evaluated against NSCLCN6 L16 bronchial epidermoid carcinoma in vitro and some of them were found to be active. N-(2-chloroethyl)-N'-(2-methoxy-9H-xanthen-9-yl)-N-nitrosourea (8e) was active against leukemia P388 tumor system in mice.