Related Experiment Videos
Chronic biofiltration therapy
V Djordjević1, S Kostić, V Stefanović
1Institute of Nephrology and Hemodialysis, Faculty of Medicine, Nis, Yugoslavia.
Artificial Organs
|August 1, 1993
Summary
Biofiltration therapy significantly reduced hypotension episodes in hemodialysis patients. This treatment also improved blood parameters, nerve function, and patient comfort over three years.
Area of Science:
- Nephrology
- Biomedical Engineering
Background:
- Acetate hemodialysis can cause symptomatic hypotension.
- Biofiltration is a potential alternative treatment.
Purpose of the Study:
- To evaluate the long-term effects of biofiltration therapy in hemodialysis patients experiencing hypotension.
Main Methods:
- A 3-year follow-up study of 7 patients undergoing biofiltration treatment.
- Monitoring of hypotension episodes, blood gas levels, beta 2-microglobulin, blood pressure, and nerve conduction velocity.
Main Results:
- A 43% reduction in symptomatic hypotension episodes.
- Significant increases in pre-treatment pH and plasma bicarbonate.
- Significant reduction in beta 2-microglobulin levels.
- Slight increases in mean systolic and diastolic blood pressures.
- Slight improvement in uremic polyneuropathy (increased motor nerve conduction velocity).
- Patients reported increased comfort during biofiltration therapy.
Conclusions:
- Long-term biofiltration therapy is effective in reducing hypotension during hemodialysis.
- Biofiltration improves acid-base balance, reduces beta 2-microglobulin, and enhances patient comfort.
- Biofiltration may offer benefits for uremic polyneuropathy in hemodialysis patients.