Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Polyphenotypic small-cell orbitocranial tumor

D B Lyon¹, R K Dortzbach, E Gilbert-Barness

¹St Luke's Medical Center, Milwaukee, Wis.

Archives of Ophthalmology (Chicago, Ill. : 1960)

|October 1, 1993

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fifteen-month-old infant with vomiting, respiratory distress, and tachypnea.

Fetal and pediatric pathology·2009

Same author

"Double-muscle" trait in cattle: a possible model for Wiedemann-Beckwith syndrome.

Fetal and pediatric pathology·2006

Same author

Vanishing bile duct syndrome: amoxicillin-clavulanic acid associated intra-hepatic cholestasis responsive to ursodeoxycholic acid.

Journal of pediatric gastroenterology and nutrition·2005

Same author

Twin-twin transfusion syndrome in a dizygotic monochorionic-diamniotic twin pregnancy.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2004

Same author

Fetal death in utero secondary to Listeria monocytogenes placental infection.

Pediatric pathology & molecular medicine·2001

Same author

Pathology teach and tell: cellular mesoblastic nephroma.

Pediatric pathology & molecular medicine·2001

Same journal

The economics of the initial preventive physical examination in medicare-reply.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

Same journal

Modification of silicone oil retention sutures in aphakic eyes with iris loss-reply;.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

Same journal

December 2011 archives web quiz winner.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

Same journal

Angle involvement and glaucoma in patients with biopsy-proven iris melanoma: a response-reply.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

Same journal

About this journal.

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

Same journal

In memoriam: goodwin m. Breinin, MD (1918-2011).

Archives of ophthalmology (Chicago, Ill. : 1960)·2013

See all related articles

A rare polyphenotypic small-cell tumor was found in an infant's orbitocranium. This undifferentiated neoplasm showed mixed epithelial, rhabdomyoblastic, and neuroectodermal differentiation.

Area of Science:

Pediatric Oncology
Skeletal System Neoplasms
Tumor Biology

Background:

Orbitocranial tumors in infants are rare and pose diagnostic challenges.
Undifferentiated small round cell neoplasms require comprehensive evaluation for accurate classification.

Observation:

A male infant presented with a massive, non-metastatic orbitocranial tumor.
Histopathology revealed a necrotic, undifferentiated small round cell neoplasm.
Ultrastructural analysis showed primitive cells with rare tight junctions and myofibrils.

Findings:

Immunohistochemistry demonstrated positivity for cytokeratin, vimentin, muscle-specific actin, neuron-specific enolase, and S100 protein.
The tumor was negative for desmin and leukocyte common antigen.

Related Experiment Videos

These findings support a polyphenotypic differentiation profile.

Implications:

This case highlights a rare polyphenotypic small-cell tumor in childhood.
Understanding its mixed differentiation is crucial for diagnosis and potential therapeutic strategies.
Further research into similar pediatric neoplasms is warranted.