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Granulocyte transfusions in children using filter-collected cells

D J Higby, A Freeman, E S Henderson

    Cancer
    |September 1, 1976
    PubMed
    Summary

    Granulocyte transfusions helped control infections in children with leukemia and neutropenia. This treatment, using filtration leukapheresis, proved beneficial for managing severe infections when antibiotics failed.

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    Area of Science:

    • Pediatric Hematology Oncology
    • Infectious Diseases in Immunocompromised Patients

    Background:

    • Children with leukemia often experience neutropenia, increasing susceptibility to severe infections.
    • Antibiotic therapy can be insufficient for managing infections in neutropenic pediatric patients.

    Purpose of the Study:

    • To evaluate the efficacy of granulocyte transfusions in treating neutropenia-associated infections in children with leukemia.
    • To assess filtration leukapheresis as a method for obtaining granulocytes for transfusion.

    Main Methods:

    • Twenty-three children with leukemia and unresponsive neutropenia-associated infections received granulocyte transfusions.
    • Granulocytes were obtained via filtration leukapheresis.
    • Treatment efficacy was assessed by fever resolution and clinical improvement.

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    Main Results:

    • Twenty-one of 23 children became afebrile during or shortly after granulocyte transfusions.
    • One patient died from disseminated Herpes simplex infection.
    • One patient was discharged but remained febrile; one child experienced a severe pulmonary reaction with pneumonia resolution.

    Conclusions:

    • Filtration leukapheresis-derived granulocyte transfusions are a useful adjunct for controlling severe infections in neutropenic children with leukemia.
    • This therapeutic approach can improve outcomes in pediatric patients with life-threatening infections unresponsive to antibiotics.