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Chimeric CD4 monoclonal antibody cM-T412 as a therapeutic approach to rheumatoid arthritis
P A van der Lubbe1, C Reiter, F C Breedveld
1Department of Rheumatology, University Hospital Leiden, The Netherlands.
Objective:
To investigate the effects of chimeric CD4 monoclonal antibody cM-T412 treatment in patients with rheumatoid arthritis (RA).
Methods:
Thirty-two RA patients received daily doses of 10, 50, or 100 mg of cM-T412 intravenously for 7 days.
Results:
There was a sustained decrease in the number of CD4+ T lymphocytes in all patients. Those who received 50 mg and 100 mg of the antibody experienced significant reductions in disease activity.
Conclusion:
Treatment with cM-T412 appears to have a dose-dependent beneficial effect in RA patients. The clinical effects of cM-T412 are independent of the depressed numbers of circulating CD4+ T cells.