Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lupus and pregnancy studies

M B Urowitz1, D D Gladman, V T Farewell

  • 1Lupus Clinic, University of Toronto, Ontario, Canada.

Arthritis and Rheumatism
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Declining levels of serum chemokine (C-X-C motif) ligand 10 over time are associated with new onset of psoriatic arthritis in patients with psoriasis: a new biomarker?

The British journal of dermatology·2020
Same author

Disease course patterns in systemic lupus erythematosus.

Lupus·2018
Same author

Secukinumab provides sustained PASDAS-defined remission in psoriatic arthritis and improves health-related quality of life in patients achieving remission: 2-year results from the phase III FUTURE 2 study.

Arthritis research & therapy·2018
Same author

Severe brady-arrhythmias in systemic lupus erythematosus: prevalence, etiology and associated factors.

Lupus·2018
Same author

Lupus myocarditis: a single center experience and a comparative analysis of observational cohort studies.

Lupus·2018
Same author

Antimalarial-induced cardiomyopathy: a systematic review of the literature.

Lupus·2017
Same journal

Proceedings of the Annual Meeting of the American Rheumatism Association.

Arthritis and rheumatism·2020
Same journal

The regional distribution of rheumatologists: what can we do, what should we do?

Arthritis and rheumatism·2013
Same journal

Regional distribution of adult rheumatologists.

Arthritis and rheumatism·2013
Same journal

Clinically significant renal involvement in primary Sjögren's syndrome: clinical presentation and outcome.

Arthritis and rheumatism·2013
Same journal

Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study.

Arthritis and rheumatism·2013
Same journal

Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate.

Arthritis and rheumatism·2013
See all related articles

Maintaining inactive systemic lupus erythematosus (SLE) before pregnancy is key for preventing flares during and after pregnancy. This contrasts with nonpregnant patients where inactive SLE offers no protection.

Area of Science:

  • Rheumatology
  • Obstetrics
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect women of childbearing age.
  • Pregnancy in SLE patients carries risks, including disease flares, necessitating understanding of prognostic factors.

Purpose of the Study:

  • To identify pre-pregnancy factors that predict disease activity during and shortly after pregnancy in SLE patients.
  • To evaluate the prognostic significance of pre-pregnancy disease status on pregnancy outcomes in SLE.

Main Methods:

  • A case-control study comparing pregnant SLE patients with nonpregnant SLE controls.
  • Logistic regression analysis was used to assess pre-pregnancy disease activity as a predictor of flares.
  • Flares were monitored during pregnancy and the postpartum period.

Related Experiment Videos

Main Results:

  • Lupus flares occurred with similar frequency in both pregnant SLE patients and nonpregnant controls.
  • Active lupus disease at study entry was not a predictor of flares in either group.
  • Inactive lupus at onset protected against flares in pregnant patients but not in nonpregnant controls.

Conclusions:

  • Achieving inactive disease status prior to conception is crucial for preventing lupus flares during pregnancy.
  • The prognostic value of inactive SLE differs between pregnant and nonpregnant patients.