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Antioxidative properties of phenazone derivatives: differentiation between phenylbutazon and mofebutazon
1Institut für Botanik und Mikrobiologie, Biochemisches Labor, Technische Universität, München.
Abstract:
Both phenylbutazon and mofebutazon inhibit oxidative fragmentation of the methionine derivative, 2-keto-4-methylthio-butyric acid (KMB) by xanthine oxidase--or diaphorase mediated OH radical production. Differentiation of the two non-steroidal antiinflammatory drugs is possible by means of determining oxygen reduction by xanthine oxidase or diaphorase in the presence of the naphthoquinone, juglone, where only mofebutazon shows an inhibitory effect.