Related Experiment Videos
Coulometric determination of some antiinflammatory compounds
K Nikolic1, M Bogavac, L Arsenijevic
1Institute of Organic Chemistry, Faculty of Pharmacy, Belgrade, Vojvode Stepe, Yugoslavia.
Farmaco (Societa Chimica Italiana : 1989)
|August 1, 1993
Summary
A new chlorocoulometric assay method allows for accurate and reproducible quantification of small amounts of piroxicam and tenoxicam. This technique is suitable for routine analysis in pharmaceutical quality control.
Area of Science:
- Analytical Chemistry
- Electrochemistry
Background:
- Piroxicam and tenoxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) with similar chemical structures.
- Accurate quantification of these drugs is essential for pharmaceutical quality control and therapeutic monitoring.
Purpose of the Study:
- To develop and validate a direct chlorocoulometric assay for the precise determination of piroxicam and tenoxicam.
- To establish a reliable method for routine analysis of these active pharmaceutical ingredients.
Main Methods:
- Direct chlorocoulometric titration using electrogenerated chloride.
- Methyl orange was employed as the indicator for the titration endpoint.
- Assay performed on small quantities of piroxicam and tenoxicam.
Main Results:
- The developed method demonstrated high accuracy and reproducibility for both piroxicam and tenoxicam.
- The assay is effective for quantifying small amounts of the investigated substances.
- The method shows potential for routine analytical applications.
Conclusions:
- The chlorocoulometric assay provides a precise and reliable method for the analysis of piroxicam and tenoxicam.
- This technique is well-suited for routine quality control in the pharmaceutical industry.
- The direct titration approach simplifies the analytical procedure.