Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD23 isoforms in murine T and B lymphocytes

R Nunez1, R G Lynch

  • 1Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
|January 1, 1993
PubMed
Summary

Murine T cells produce the low affinity IgE Fc receptor (CD23), with some cells expressing alternatively spliced CD23 transcripts potentially encoding soluble forms. This research provides evidence for CD23 production by T lymphocytes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Translated article] A perioperative optimisation programme can improve results and reduce hospital length of stay in hip and knee arthroplasty: Experience in Chile.

Revista espanola de cirugia ortopedica y traumatologia·2026
Same author

Precision medicine and glaucoma management: how mathematical modeling and artificial intelligence help in clinical practice.

Expert review of ophthalmology·2022
Same author

Normal Baseline Values for Isometric Shoulder Strength in Scaption for Healthy Filipino Individuals in the 20-30 year Age Group.

Malaysian orthopaedic journal·2021
Same author

Improvement in clinical outcomes and replacement factor VIII use in patients with haemophilia A after factor VIII pharmacokinetic-guided prophylaxis based on Bayesian models with myPKFiT<sup>®</sup>.

Haemophilia : the official journal of the World Federation of Hemophilia·2018
Same author

Carborane-stilbene dyads: the influence of substituents and cluster isomers on photoluminescence properties.

Dalton transactions (Cambridge, England : 2003)·2017
Same author

Icosahedral boron clusters: a perfect tool for the enhancement of polymer features.

Chemical Society reviews·2016

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • The low affinity IgE Fc receptor (CD23) is crucial in allergic responses and immune regulation.
  • Its expression and function on T cells, particularly in mice, remain incompletely understood.

Purpose of the Study:

  • To investigate biochemical evidence for CD23 production by murine T cells.
  • To characterize CD23 mRNA transcripts in various T cell populations.
  • To explore the implications of alternative splicing in CD23 gene expression.

Main Methods:

  • Analysis of CD23 mRNA expression in murine T cell populations.
  • Nucleotide sequencing of CD23 transcripts.
  • Investigation of alternative splicing events in CD23 gene expression.

Related Experiment Videos

Main Results:

  • Most analyzed murine T cell populations express CD23 mRNA.
  • Identical CD23 cDNA sequences were found in some T and B cells, matching those from B cells.
  • Truncated CD23 transcripts, generated by alternative splicing, were detected in T and B cells, potentially encoding soluble CD23 isoforms.

Conclusions:

  • Murine T lymphocytes produce CD23.
  • Alternative splicing of CD23 transcripts occurs in both T and B cells, suggesting the existence of CD23 isoforms.
  • These findings offer new insights into CD23 structure, isoforms, and production by murine lymphocytes.