Related Experiment Video
Updated: Aug 11, 2026

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
Published on: July 28, 2010
T-cell and cytokine responses in leishmaniasis
Abstract:
Intracellular pathogens, particularly those that inhabit lymphocytes and macrophages, represent unique challenges to the immune system. Leishmania are protozoan parasites that replicate exclusively in macrophages and are thus in an excellent position to influence lymphocyte responses. T cell responses are critical in determining the outcome of infections with Leishmania. In both murine and human infections, strong T helper type 2 responses have been associated with disease, and a decreased or absent T helper type 2 response has been associated with healing.
More Related Videos
Related Concept Videos
Cell-mediated Immune Responses
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Leishmaniasis
Antiprotozoal Agents

