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Oestrogen effects on osteoblasts and osteoclasts

M J Oursler1, J P Landers, B L Riggs

  • 1Department of Biochemistry and Molecular Biology, Mayo Foundation, Mayo Clinic, Rochester, MN 55905.

Annals of Medicine
|August 1, 1993
PubMed
Summary
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Estrogen plays a crucial role in bone balance. Recent research reveals estrogen receptors in osteoblasts and osteoclasts, clarifying its direct effects on bone cells and bone remodeling.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Molecular Mechanisms

Background:

  • Estrogen is vital for maintaining bone balance.
  • The precise mechanisms of estrogen's influence on bone have been unclear.
  • Estrogen receptors (ERs) are now identified in osteoblasts and osteoclasts.

Purpose of the Study:

  • To present an updated model of molecular mechanisms in estrogen action.
  • To elucidate the mechanism of anti-estrogen action.
  • To outline recent advances in understanding estrogen's effects on bone cells and bone remodeling.

Main Methods:

  • Review of current literature on estrogen and bone biology.
  • Analysis of molecular pathways involving estrogen receptors.
  • Synthesis of findings on osteoblast and osteoclast activity.

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Main Results:

  • Estrogen directly impacts both bone-forming osteoblasts and bone-resorbing osteoclasts.
  • A refined model for estrogen's molecular mechanisms of action is proposed.
  • Understanding of anti-estrogen action has advanced.
  • New insights into the coupling of bone resorption and formation are presented.

Conclusions:

  • Estrogen exerts direct effects on bone cells, influencing bone remodeling.
  • The identified estrogen receptors are key to understanding estrogen's role in bone health.
  • This review provides a comprehensive overview of current knowledge and future research directions.