[Intrapulmonary instillations in destructive tuberculosis]

Area of Science:

• Pulmonology
• Infectious Diseases
• Pharmacology

Context:

• Destructive tuberculosis, characterized by pulmonary decay, poses a significant clinical challenge.
• Intrapulmonary instillations represent a therapeutic approach for managing advanced tuberculosis.
• The study was conducted at the Kostroma Regional Tuberculosis Dispensary between 1985 and 1991.

Purpose:

• To evaluate the efficacy of intrapulmonary instillations of saluside and tubaside solutions in treating destructive tuberculosis.
• To compare the outcomes of intrapulmonary instillations alone versus in combination with surgery.

Summary:

• A 5% saluside solution (15.0 ml) and a 10% tubaside solution (6.0 ml) were administered via intrapulmonary instillations.
• The primary indication for this treatment was pulmonary decay.
• Cavity closure was observed in 32.9% of cases with instillations alone and 50% when combined with surgery.
• For primary patients, these rates were 42.4% and 66.2%, respectively.

Impact:

• Intrapulmonary instillations, especially when combined with surgery, demonstrate a notable improvement in achieving cavity closure in destructive pulmonary tuberculosis.
• This therapeutic strategy offers a viable option for managing complex tuberculosis cases with pulmonary decay.
• The findings contribute to understanding treatment outcomes for advanced tuberculosis in a specific clinical setting.