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Colon cancer in seven siblings

P Ghadirian1, M Cadotte, A Lacroix

  • 1Faculty of Medicine, Department of Nutrition, Hôtel-Dieu de Montréal Hospital, Canada.

European Journal of Cancer (Oxford, England : 1990)
|January 1, 1993
PubMed
Summary

A case-control study found a significantly higher rate of colon cancer in families with a history of the disease. This suggests both genetic and environmental factors contribute to colon cancer development.

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Area of Science:

  • Oncology
  • Genetics
  • Epidemiology

Background:

  • Colon cancer presents a significant public health challenge.
  • Understanding the role of family history in colon cancer etiology is crucial for risk assessment and prevention strategies.

Purpose of the Study:

  • To investigate the association between family history and the risk of developing colon cancer.
  • To explore the characteristics of familial colon cancer cases.

Main Methods:

  • A case-control study design was employed.
  • Data collection included family history of colon cancer and pathological diagnoses.
  • A detailed follow-up study was conducted on one high-risk family.

Main Results:

  • 29% of colon cancer cases had a positive family history compared to 4% of controls.
  • One family exhibited a high prevalence of colon cancer among siblings (7 out of 12).
  • Familial cases were diagnosed at a mean age of 64, with tumors located in the caecum or right colon.

Conclusions:

  • A positive family history is a significant risk factor for colon cancer.
  • Both genetic predisposition and environmental factors likely contribute to the development of colon cancer.
  • Further research into familial colon cancer is warranted to identify specific genetic and environmental influences.

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