Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional neuroimaging with single photon emission computed tomography (SPECT)

D J Wyper1

  • 1Department of Clinical Physics, Southern General Hospital, Glasgow, Scotland.

Cerebrovascular and Brain Metabolism Reviews
|January 1, 1993
PubMed
Summary

Single photon emission computed tomography (SPECT) offers a cost-effective functional neuroimaging alternative to positron emission tomography (PET). SPECT enables visualization of cerebral blood flow, tumor viability, and neurotransmitter systems, expanding clinical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alterations in nicotinic α4β2 receptor binding in vascular dementia using ¹²³I-5IA-85380 SPECT: comparison with regional cerebral blood flow.

Neurobiology of aging·2009
Same author

Alpha4beta2 nicotinic receptor status in Alzheimer's disease using 123I-5IA-85380 single-photon-emission computed tomography.

Journal of neurology, neurosurgery, and psychiatry·2006
Same author

Effects of level of retrieval success on recall-related frontal and medial temporal lobe activations.

Behavioural neurology·2002
Same author

Spatial normalization of lesioned HMPAO-SPECT images.

NeuroImage·2001
Same author

Applications of SPECT in cognitive neuroscience, neurology and psychiatry.

Behavioural neurology·2001
Same author

Analysis of HMPAO SPECT scans in head injury using Statistical Parametric Mapping.

Behavioural neurology·2001

Area of Science:

  • Nuclear Medicine
  • Functional Neuroimaging

Background:

  • Single photon emission computed tomography (SPECT) provides regional in vivo distribution maps of radiolabeled tracers.
  • SPECT utilizes readily available tracers (e.g., 99mTc, 123I) and gamma cameras, reducing complexity and cost compared to positron emission tomography (PET).

Purpose of the Study:

  • To provide an overview of SPECT's functionality and established applications in various pathologies.
  • To highlight SPECT's role as an accessible functional imaging technique for clinicians.

Main Methods:

  • Review of SPECT principles and applications.
  • Discussion of tracer characteristics and imaging technology.

Main Results:

  • SPECT allows imaging of cerebral blood flow, tumor viability, and neurotransmitter receptor systems.

Related Experiment Videos

  • SPECT is significantly less expensive than PET, eliminating the need for on-site cyclotrons.

    • Conclusions:

    • SPECT, despite technical limitations, is a valuable and widely accessible functional neuroimaging tool.
    • Its expanding applications offer broad clinical benefits, complementing PET in diagnosing and researching various pathologies.