Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The bone marrow in murine AIDS

M Magnani1, G Brandi, L Rossi

  • 1Istituto di Chimica Biologica G. Fornaini, Università degli Studi di Urbino, Italy.

British Journal of Haematology
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

D-Dimer levels during pregnancy and postpartum: non-applicability of regularly used cut-offs for diagnosis of suspected pulmonary embolism.

Archives of gynecology and obstetrics·2026
Same author

KRAS mutations in colorectal cancer patients receiving trifluridine/tipiracil plus bevacizumab: something to consider.

ESMO open·2025
Same author

Cholangiocarcinoma patients with FGFR2 fusions/rearrangements but primary refractory to pemigatinib: the real challenge?

ESMO open·2024
Same author

Sex-related differences of invasive therapy in patients with aneurysmal subarachnoid hemorrhage.

Acta neurochirurgica·2022
Same author

Active breaks: a strategy to counteract sedentary behaviors for Health Promoting Schools. A discussion on their implementation in Italy.

Annali di igiene : medicina preventiva e di comunita·2022
Same author

Effect of COVID-19 isolation measures on physical activity of children and their parents, and role of the family environment: a cross-sectional study.

Annali di igiene : medicina preventiva e di comunita·2022
Same journal

Author response to Zhang and Chen.

British journal of haematology·2026
Same journal

Response-adapted chimeric antigen receptor T cell (CAR-T)-sparing consolidation radiotherapy in high-risk large B-cell lymphoma (LBCL): Results of the prospective RESTART protocol.

British journal of haematology·2026
Same journal

Prospective, multicentre phase II study to evaluate the clinical benefit of reduced-dose lenalidomide and dexamethasone based on frailty stratification in elderly, unfit patients with newly diagnosed multiple myeloma.

British journal of haematology·2026
Same journal

Real-world effectiveness and safety of acalabrutinib in chronic lymphocytic leukaemia: Multicentre experience.

British journal of haematology·2026
Same journal

Novel germline GATA1s-generating variant associates with somatic STAG2 variants in hypoplastic myelodysplastic neoplasm.

British journal of haematology·2026
Same journal

The Endothelial Activation and Stress Index (EASIX) at diagnosis is associated with survival in primary central nervous system lymphoma.

British journal of haematology·2026
See all related articles

Murine AIDS (MAIDS) bone marrow shows reduced cellularity and erythroid precursors, with increased eosinophils and lymphocytes. This MAIDS model mirrors human advanced AIDS bone marrow, aiding blood cytopenias research.

Area of Science:

  • Immunology
  • Hematology
  • Virology

Background:

  • Blood cytopenias are common in HIV infection.
  • Understanding bone marrow changes in HIV is crucial for treatment.
  • Murine models offer insights into human diseases.

Purpose of the Study:

  • To investigate bone marrow alterations in murine AIDS (MAIDS).
  • To assess the utility of MAIDS as a model for HIV-related blood cytopenias.

Main Methods:

  • C57BL/6 mice were infected with the LP-BM5 retrovirus to induce MAIDS.
  • Bone marrow cellularity and cell populations were analyzed.
  • Immunostaining with an anti-Pr60gag antibody was performed.

Main Results:

Related Experiment Videos

  • MAIDS bone marrow exhibited decreased cellularity and erythroid precursor cells.
  • Increased numbers of haemophagocytic histiocytes, eosinophils, and lymphocytes were observed.
  • Viral protein expression was detected in the majority of bone marrow cells.

    • Conclusions:

    • MAIDS bone marrow shares similarities with human advanced AIDS bone marrow.
    • The MAIDS model is valuable for studying and treating HIV-associated blood cytopenias.